Historical Tracing and Textual Research on Ancient Classic Formula Zhenwutang / 中国实验方剂学杂志

ZHANG Zhongjing's Zhenwutang is a classic formula for warming Yang and excreting water. It is composed of Aconiti Lateralis Radix Praeparata， Poria， Atractylodis Macrocephalae Rhizoma， Paeoniae Radix Alba， and Zingiberis Rhizoma Recens. Physicians of later generations have inherited and developed this formula by detailed recording and application. This paper adopted bibliometrics method to analyze Zhenwutang in terms of history， indications， dosage， drug processing， usage， and modification. The results showed that Zhenwutang was most widely used in Ming and Qing dynasties. Many physicians have inherited ZHANG Zhongjing's theory regarding the application of Zhenwutang in disease treatment， and a few physicians have used it to treat diphtheria and water-related diseases. Some physicians modified this formula to treat maculae， intermittent dysentery， jaundice and so on. Zhenwutang was mainly used to treat diseases of the circulatory system， respiratory system and urinary system in modern clinical practice. The processing of herbal medicines in this formula was clear. Specifically， the raw material of Aconiti Lateralis Radix Praeparata needed to be processed and peeled， while those of Poria， Atractylodis Macrocephalae Rhizoma， Paeoniae Radix Alba， and Zingiberis Rhizoma Recens can be used directly. Although being different， most of the dosages were consistent with those in Treatise on Febrile Diseases. According to the textual research， it is suggested that the reference dosage of this prescription in clinical practice is 41.25 g for Poria， Paeoniae Radix Alba， and Zingiberis Rhizoma Recens， respectively， 27.5 g for Atractylodes macrocephala， and 15 g for Aconiti Lateralis Radix Praeparata. The medicinal materials should be decocted in 1 600 mL water to reach a volume of 600 mL. After removal of the residues， the decoction should be taken warm with 140 mL each time， three times a day. The textual research of Zhenwutang is expected to provide a theoretical reference for the clinical application and formulation of Zhenwutang.

Zhenwu Decoction:connotation interpretation based on severe cases and modern pathophysiological mechanisms and application in treatment of heart failure in critical care unit / 中国中药杂志

Zhenwu Decoction is recorded in Treatise on Febrile Diseases by an outstanding physician ZHANG Zhong-jing in the Han dynasty. With effect of warming yang, transforming Qi, and promoting urination, Zhenwu Decoction is mainly used to treat edema due to yang deficiency. The studies of the severe and critical cases and the pathophysiological mechanisms have demonstrated that the record of Zhenwu Decoction in Treatise on Febrile Diseases describes the clinical symptoms and therapeutic regimen of acute heart failure. The syndrome treated by this formula may be related to the misdiagnosis and wrong treatment. Due to the difficult distinguishing between cardiogenic dyspnea and pulmonary dyspnea, high doses of Ephedrae Herba may be misused for inducing sweating, which may finally lead to the acute aggravation of heart failure, electrolyte disorder, and pulmonary infection. The syndrome treated by Zhenwu Decoction can illustrate the lack of experience of ancient physicians in treating acute heart failure. The description of "trembling and shivering" may be the clinical manifestation of heart failure, which is an upgraded version of "trembling and shaking" treated by Linggui Zhugan Decoction.(1)In terms of diseases, Zhenwu Decoction is suitable for the treatment of acute or chronic heart failure, cardiorenal syndrome, and diuretic resistance. The decoction is especially suitable for treating whole heart failure, acute heart failure, heart failure with reduced ejection fraction, and heart failure with the syndrome of sold and dampness. In addition, it can be used to treat both type Ⅱ and type Ⅳ cardiorenal syndrome.(2)In terms of symptoms, Zhenwu Decoction can be used for treating chest tightness, palpitations, lower limb edema, difficult urination or increased urine output, fear of cold, pale fat tongue with teeth marks, white and slippery tongue fur, and deep or slow pulse.(3)In terms of the pharmacological mechanism, Zhenwu Decoction treats heart failure following the principle of promoting urination, expanding blood vessels, and invigorating heart in modern medicine. Aconiti Lateralis Radix Praparata is the sovereign herb in the formula, with the recommended dosage of 30-60 g. However, arrhythmia may be caused by high doses of Aconiti Lateralis Radix Praparata, which should be used with concern. In addition to Zhenwu Decoction, Shenqi Pills, Renshen Decoction, Wuling Powder, and Fangji Huangqi Decoction with the effect of invigorating spleen, replenishing Qi, warming Yang, and promoting urination can be used in the recovery stage. The therapy of reinforcing Yang was the last choice for critical cases due to the lack of medical conditions, unclear clinical diagnosis in history, which should be treated objectively now.

Heterogeneous graph construction and node representation learning method of Treatise on Febrile Diseases based on graph convolutional network / 数字中医药（英文）

Objective@#To construct symptom-formula-herb heterogeneous graphs structured Treatise on Febrile Diseases (Shang Han Lun,《伤寒论》) dataset and explore an optimal learning method represented with node attributes based on graph convolutional network (GCN).@*Methods@#Clauses that contain symptoms, formulas, and herbs were abstracted from Treatise on Febrile Diseases to construct symptom-formula-herb heterogeneous graphs, which were used to propose a node representation learning method based on GCN − the Traditional Chinese Medicine Graph Convolution Network (TCM-GCN). The symptom-formula, symptom-herb, and formula-herb heterogeneous graphs were processed with the TCM-GCN to realize high-order propagating message passing and neighbor aggregation to obtain new node representation attributes, and thus acquiring the nodes’ sum-aggregations of symptoms, formulas, and herbs to lay a foundation for the downstream tasks of the prediction models.@*Results@#Comparisons among the node representations with multi-hot encoding, non-fusion encoding, and fusion encoding showed that the Precision@10, Recall@10, and F1-score@10 of the fusion encoding were 9.77%, 6.65%, and 8.30%, respectively, higher than those of the non-fusion encoding in the prediction studies of the model.@*Conclusion@#Node representations by fusion encoding achieved comparatively ideal results, indicating the TCM-GCN is effective in realizing node-level representations of heterogeneous graph structured Treatise on Febrile Diseases dataset and is able to elevate the performance of the downstream tasks of the diagnosis model.

Construction and application of knowledge graph of Treatise on Febrile Diseases / 数字中医药（英文）

Objective@#To establish the knowledge graph of “disease-syndrome-symptom-method-formula” in Treatise on Febrile Diseases (Shang Han Lun,《伤寒论》) for reducing the fuzziness and uncertainty of data, and for laying a foundation for later knowledge reasoning and its application.@*Methods@#Under the guidance of experts in the classical formula of traditional Chinese medicine (TCM), the method of “top-down as the main, bottom-up as the auxiliary” was adopted to carry out knowledge extraction, knowledge fusion, and knowledge storage from the five aspects of the disease, syndrome, symptom, method, and formula for the original text of Treatise on Febrile Diseases, and so the knowledge graph of Treatise on Febrile Diseases was constructed. On this basis, the knowledge structure query and the knowledge relevance query were realized in a visual manner. @*Results@#The knowledge graph of “disease-syndrome-symptom-method-formula” in the Treatise on Febrile Diseases was constructed, containing 6 469 entities and 10 911 relational triples, on which the query of entities and their relationships can be carried out and the query result can be visualized. @*Conclusion@#The knowledge graph of Treatise on Febrile Diseases systematically realizes its digitization of the knowledge system, and improves the completeness and accuracy of the knowledge representation, and the connection between “disease-syndrome-symptom-treatment-formula”, which is conducive to the sharing and reuse of knowledge can be obtained in a clear and efficient way.

Huanglian Ejiao Decoction formula syndrome and its application for refractory insomnia / 中国中药杂志

Huanglian Ejiao Decoction,firstly recorded in Treatise on Febrile Diseases,could be used to treat heat-conversion syndrome of Shaoyin. It has been identified that,the indications of Huanglian Ejiao Decoction include:(1)in modern medicine,it can be used to treat insomnia,arrhythmia,oral ulcer,Xiali,blood syndrome and other diseases;(2)in terms of symptoms and signs,it is mainly used for restlessness,ritability,insomnia,extremely difficult to fall asleep,palpitation,atrial premature beat,ventricular premature beat and other arrhythmias,stomach distension and stuffiness,stomach pain,vomiting,abdominal pain,cramps,lower edge,constipation,blush,red lips,easy bleeding,red tongue,thin or no coating,dry tongue surface,or light red tongue,or dark red,thin white tongue coating,and rapid pulse. It has been also identified that,(1)although the original statement of Huanglian Ejiao Decoction is very simple,it can not only be used according to irritability and insomnia;(2)tongue image is not the key to syndrome differentiation of this prescription;(3)the essence of Shaoyin syndrome is not completely heart kidney Yang deficiency,which is closest to shock in modern medicine,including septic shock,hypovolemic shock and cardiogenic shock;(4)the essential difference between Shaoyin cold and heat conversion syndrome of Shaoyin lies in the different types of shock,in which cardiogenic shock is the main cold type,while septic shock is the main heat shock;(5)heat-conversion syndrome of Shaoyin is more common in the late stage of septic shock,and part of it can be seen in the stage of heart failure combined with sympathetic activation;(6)Dioscoreae Rhizoma and Rehmanniae Radix are often used to replace egg yolk;(7)Huanglian Ejiao Decoction takes effect quickly and the course of treatment is short.

Empirical Analysis and Modern Research of Zhenwutang / 中国实验方剂学杂志

Zhenwutang is the classic formula of Wenyang Lishui in " <italic>Treatise on Febrile Diseases</italic>" . It consists of five kinds of medicines, namely Aconiti Lateralis Radix Praeparata, Zingiberis Rhizoma Recens, Atractylodis Macrocephalae Rhizoma, Poria, Paeoniae Radix Alba or Paeoniae Radix Rubra. It has been included in the <italic>Catalogue of Ancient Classics</italic> (<italic>The First Batch</italic>) issued by the State Administration of Traditional Chinese Medicine in 2018.There are two articles in the " <italic>Treatise on Febrile Disease</italic>s" about the syndromes of Zhenwutang. On the basis of Article 82 of the Chapter of Taiyang disease, the Taiyang disease is demonstrated by sweating, but after that the patient still suffers from fever, epigastric throb, dizziness and shiver, this shall be treated with Zhenwutang. According to Article 316 of the chapter of Shaoyin disease, Shaoyin disease lasts for two or three days, until the fourth and fifth days, and is demonstrated by abdominal pain, difficult urination, severe pain in the limbs and diarrhea, the patient have a cough, diuresis, diarrhea and vomit, this shall be treated with Zhenwutang. The original texts discuss the basic pathogenesis is edema syndrome due to Yin and Yang deficiency, with symptoms of unfavorable urination, heavy limbs or edema, pale tongue, white moss and heavy pulse as dialectical points. In terms of the compatibility of prescriptions, usage and dosage, and the interpretation of prescriptions, this paper examines Zhenwutang syndromes in " Treatise on Febrilediseases" , summarizes the material basic research of Zhenwutang, and provides the basis for the quality control of its compound pharmacodynamics. This study summarizes the progress of pharmacological research for Zhenwutang in recent years, finds that Zhenwutang has many efficacies, such as cardiotonic, diuretic, lowering lipid, anti-oxidation, improving renal function and balancing of water and liquid metabolism, lists traditional Chinese medicine(TCM) syndromes treated with Zhenwutang, such as heart palpitations, edema, cough, abdominal pain, sipping, dizziness, and Western medicine diseases, like congestive heart failure, pulmonary heart disease, bronchial asthma, chronic colitis, cirrhosis, ascites, chronic glomerulonephritis, chronic renal failure, benign prostatic hyperplasia and Meniere's syndrome, expounds the principle of Zhenwutang for " treating different diseases with the same therapy" , in order to provide useful reference for the research and development and clinical application of Zhenwutang and more classic prescriptions.

Gegen Qinlian Decoction formula syndrome and its application in diabetes, hypertension, hyperlipidemia and obesity / 中国中药杂志

Gegen Qinlian Decoction can be used to treat intestinal dampness and heat. In addition to diarrhea diseases, it is also commonly used in the treatment of diabetes, hypertension, hyperlipidemia, obesity and other chronic metabolic diseases. It can not only alleviate symptoms, but also reduce blood sugar, blood pressure, lipid and weight. Neck stiffness, blush, red lips, red tongue, dry mouth, sweating, palpitation, insomnia and feces are the key indications of Gegen Qinlian Decoction. It can be used alone to reduce blood sugar for diabetes mellitus. In the treatment of hypertension, it can reduce blood pressure when being used alone or combined with Tianma Gouteng Yin or Chaihu Jia Longgu Muli Decoction. Large dose(30-120 g) of Pueraria lobata is the key to the effect of Gegen Qinlian Decoction.

Research on Development of Preparations in Traditional Chinese Medicine Classics During the Han,Tang and Song Dynasties / 中国实验方剂学杂志

This paper compared and analyzed the relevant records of Chinese medicine pharmacy in the Han,Tang and Song dynasties,and summarized the changes of the dosage forms,preparation techniques and administration methods of Chinese medicine with the development of history.In this study,three classic medical works in the Han,Tang and Song dynasties,including Treatise on Febrile Diseases Caused by Cold,Valuable Prescriptions for Emergency and Formularies of the Bureau of People's Welfare Pharmacies,were taken as the research objects,and the development of the dosage forms,auxiliary materials,preparation technology and medication theory were summarized and explored by the ways of content analysis,comparative analysis and case analysis.The comparison showed that in the development process,the dosage forms gradually increased,but the liquid dosage forms gradually decreased,the solid dosage forms gradually increased.Not only the dosage forms varied in the number,types of excipients used more and more,but the level of preparation had been constantly improved while the methods of taking became more detailed.This evolution of dosage forms and pharmaceutical technologies in Chinese history is worth learning and thinking about it.Through exploring the traditional Chinese medicine(TCM) technologies and theories in the Han,Tang and Song dynasties,we can contribute to the inheritance of traditional preparations and it can provide the basis for the development of modern preparations with TCM characteristics.

Study on the Application of ZHANG Zhicong's Theory of the Combination of Wu and Gui / 浙江中医药大学学报

[Objective]To study the application of ZHANG Zhicong to the combination of Wu and Gui. [Method]Analyse the ZHANG Zhicong's explaining'Huang Di Nei Jing' and 'Shanghan Lun'and his monographs, through the theory of 'the combination of Wu and Gui'.[Result]ZHANG Zhicong's application has following traits:(l)Attach importance to the relationship of stomach and the kidney.(2)From the point of the view of Shanghan Lun, it can be summarized as'whether Shaoyin getting the warm of Yangming'. (3)The application combined with the theories of 'Zang and Fu 'and six-meridian and ' Qi and blood'.[Conclusion]ZHANG Zhicong used the theory of the combination of Wu and Gui to describe Chinese medical theory and herb and cases.lt is an inovation on theory, though it hasn't been systematized.

Exploration on the application of Qimen (LR 14) in / 中国针灸

In , had used Qimen (LR 14) for the most times compared with other acupoints among the limited numbers of acupuncture prescriptions. Qimen (LR 14) is the front- point of the liver meridian, acting on smoothing liver and regulating activity. It is commonly used to treat the disorders caused by retarded circulation of and blood, such as distension and pain of the hypochondriac region and masses. Based on the opening-closing-pivot theory of the six meridians, the specificity of the running course of the meridian and the property of Qimen (LR 14), the mechanisms of Qimen (LR 14) were analyzed on the treatment of febrile diseases, aiming to enhance the considerations and application of this points in clinical practice and contribute to the further understanding of ' s academic thoughts on the syndrome differentiation in the treatment of diseases.

Treatise on Febrile Diseases and critical care medicine: exploring connotation of original, dosage, and essence of six meridians from perspective of critical care medicine and integrative medicine / 中国中药杂志

Treatise on Febrile Diseases is one of the greatest classics in traditional Chinese medicine. Currently, so many key scientific problems including unclear connotation of the original, dosage of Chinese herbal medicine, and the essence of the six meridians were identified. On the basis of years of clinical experience in critical care medicine, it was advocated that the connotation of Treatise on Febrile Diseases should be explored from the perspective of critical care medicine and integrative medicine. It was identified that, the traditional study from the perspective of pathogenesis and textual research couldn't meet the current clinical needs due to its repeated deduction and circular argument in conceptual terms and unclear diagnosis and prognosis of modern diseases. The concept of exogenous febrile disease is the narrow sense, the essence of which may be acute febrile infectious diseases. Treatise on Febrile Diseases is a monographs for critical care medicine. The clinical manifestation of so many critical care medicine can be identified in Treatise on Febrile Diseases. The distinction standard of Treatise on Febrile Diseases and Synopsis of Golden Chamber is not external injury but contagious disease. The dosage problem in Treatise on Febrile Diseases mainly refers to large dose. The essence of six meridians in Treatise on Febrile Diseases is severe infection. Six meridians are different stages of severe infection, including the inflammation-based three Yang stages and deficiency-based three Yin stages. Additionally, the six meridians could be recognized by look, while not speculation. The struggle between cold and warm schools could be unified based on our research. The most direct and fundamental methods in studying Treatise on Febrile Diseases lies in critical care medicine and integrative medicine. The modern research of Treatise on Febrile Diseases is intensely calling for new treatment principle based on pathogenesis combined with pathology and property combined with pharmacology. Therefore, cultivation of ability in critical care medicine and integrative medicine should be emphasized in future studies.

Connotation interpretation of "only one syndrome is evident for disease" in Treatise on Febrile Diseases by Zhang Zhongjing / 中国中药杂志

"Only one syndrome is evident for disease", a clinical guiding ideology in the Treatise on Febrile Diseases proposed by Zhang Zhongjing, has caused widespread controversy among physicians over the ages. The core lies in the divergence of the understanding of "one syndrome". The reason is that although many physicians sum up experience on the basis of their clinical experience, the premise of the clinical environment is ignored when interpreting the connotation. On the one hand, "only one syndrome is evident for disease" emphasizes the flexibility of grasping the main symptoms clinically. On the other hand, it emphasizes the evidence sufficiency of "one syndrome" as the basis for diagnosis. Generally speaking, specific symptoms are higher evidence as a basis for diagnosis. However, because of the clinical complexity, the symptoms with lower specificity, less targeting and lower evidence strength in common cases may become the key points of the final prescription selection in specific cases sometimes, increasing the strength of evidence and becoming the only important factor in determining the overall situation. In addition to the objective clinical conditions, some subjective factors such as clinical level and academic quality of the physicians are also important factors that affect the clinical application of "only one syndrome is evident for disease". Therefore, it is necessary to not only pay attention to the clinical objective conditions, but also try to improve the physicians' clinical level, appreciate the "only one syndrome is evident for disease" thought in the clinical environment, which is the key to solve this problem.

Analysis on Some Problems of Taiyang Disease and Blood Storage Syndrome / 浙江中医药大学学报

[Objective] To explore the location and pathogenesis of Taiyang disease and blood storage syndrome. [Method]This article starts from the controversy about the position of Taiyang disease and blood storage syndrome of the past dynasties,analyzing and defining 4 related problems layer by layer,and expounding the position, etiology, pathogenesis and other problems of Taiyang disease and blood storage syndrome. [Results]Firstly, "urine self benefit" means that the Taiyang disease and blood storage syndrome is not located in the bladder,it is wrong idea that typhoid scholar considers the idea of "blood storage bladder";Secondly, "bleeding" does not mean bleeding in the urine, mainly refers to blood stasis from feces,also referred to bleeding caused by female cytoplasmic disease; Thirdly, the "hot knot bladder" does not refer to the bowels of the bladder, it refers to that lower focal low abdominal position;Fourthly, "hot knot bladder" and "hot in the lower coke" have the same connotation,the emphasis is on explaining the etiology and pathogenesis of Taiyang disease and blood storage syndrome, that being the surface evil of Taiyang typhoid disease is not relieved, evil heat progressing into the small intestine,or liver(Jueyin) and uterus,blood stasis and heat poison intersecting in the lower focal and lower abdomen;Fifthly, the specific location of hypofocal disease in the small intestine or uterus and other abdominal parts.[Conclusion]The position of Taiyang disease and blood storage syndrome is not in the bladder, but in the lower abdomen.The etiology and pathogenesis is that the surface evil of Taiyang typhoid disease is not relieved, evil heat progressing into the small intestine,or liver(Jueyin) and uterus,blood stasis and heat poison intersecting in the lower focal and lower abdomen.

Reveal of the 374th Clause of Treatise on Febrile Disease / 浙江中医药大学学报

[bjective]This paper is about to expound the true meaning of the 374th clause of Treatise on Febrile Diseases. [Methods] Under the guidance of dynamic thinking of Treatise on Febrile Diseases, with the help of other clauses about Zaoshi syndrome, Small Decoction for Ordering the Qi, Gardenia and Prepared Soybean Decoction, to understand the 374th clause.[Results] The 374th clause is not alone, it should be combined with the 375th clause, they tell us when we treat the combination of Shi and Re syndrome of Yangming disease, we should use Small Decoction for Ordering the Qi first, then use Gardenia and Prepared Soybean Decoction. At the same time if we want to understand the 374th clause, we should combine it with the 368th clause to 375th clause, it tells us the treatment and difference between the diarrhea of cold, wet heat, Shi and Re, deficient heat etc. [Conclusion]This clause institutes the principle of the treatment for Shi and Re syndrome of Yangming disease, completing the system of treating diarrhea. It also tells us how to combine two decoctions.

Analysis of Composition and Medication Regularities of Prescriptions for Treatise on Febrile Diseases Based on TCM Inheritance Platform System(V2.5)Software / 中国药房

OBJECTIVE:To investigate the composition and medication regularities of prescriptions for Treatise on Febrile Dis-eases. METHODS:The prescriptions included in Treatise on Febrile Diseases were collected and inputted into TCM inheritance platform system(V2.5)software,and prescription database was established. The medication and the compatibility regularity of pre-scriptions were excavated using the function of software integration. RESULTS & CONCLUSIONS:83 kinds of TCM involved in 112 prescriptions ranked by frequency,among which 24 ingredients were used more than 4 times. Commonly used TCM groups were summarized to evolve 16 key groups and 8 new prescriptions. Four properties of TCM are mainly the property of“Wen and Han”,and five tastes mostly are“Sweet,Bitter,Spicy”. TCM with the property of“Wen and Sweet”taste are more than those with the property of“Wen and Spicy”,and TCM acting on spleen are more than those acting on lung.

Exploring and Analyzing the Medication Characteristics of Treating Cough and Dyspnea in Treatise on Febrile Diseases / 浙江中医药大学学报

Objective]To research and explore the characteristic of medicine in Treatise on Febrile Diseases. [Methods]Combine with the doctors of past dynasties, relevant annotations of the treatment of cough notes in Treatise on Febrile Diseases,and my own learning experience,analyze the characteristic of medicine of Zhongjing treating cough in Treatise on Febrile Diseases.[Results]Its characteristics are summed up in three points.Pay attention to the thought of the simultaneous dispersion and descending, and conform to lung qi.Pay attention to the drugs of the lung channel,especially the application of Ephedra and its compatibility with other drugs.Pay attention to“reinforcing earth to generate metal”and protect stomach qi. [Conclusion]The research of this paper is beneficial to broaden the clinical treatment of cough ideas,expand the clinical application of the classical prescription,deepen the understanding of Zhang Zhongjing's academic thought.

Correlation between active components alignment and medicinal function of Peony and Licorice decoction / 国际药学研究杂志

Objective: To study the change regulation of nine compounds(oxypaeoniflorin, albiflorin, paeoniflorin, benzoyl-paeoniflorin, glycyrrhizic acid, liquiritin, isoliquiritin, liquiritigenin, and isoliquiritigenin) in Peony and Licorice decoction, and analyze the correlation between therapeutical effects and active components alignment. Methods: Classical prescription Peony and Licorice decoction (Shanghanlun) were taken as the carrier, five different combinations of Peony and Licorice decoction were used as the control, and the content was determined by HPLC-DAD. Results: The contents of nine compounds of different combinations of Peony and Licorice decoction was(mg/ml): Shanghanlun 1.92, 0.90, 3.51, 0.53, 8.35, 3.16, 0.77, 0.77 and 0.15; Chuanxinshiyongfang 0.92, 0.45, 1.62, 0.37, 0.78, 0.34, 0.06, 0.10 and 0.01, Zhushijiyanfang A 1.59, 0.82, 3.28, 0.49, 3.15, 1.10, 0.27, 0.44 and 0.08, Zhushijiyan-fang B 1.14, 0.52, 2.12, 0.41, 2.92, 0.97, 0.22, 0.36 and 0.06, Weishijiacangfang 1.38, 0.59, 2.70, 0.43, 2.40, 0.35, 0.06, 0.10 and 0.01, Yi-menbafang 1.52, 0.67, 2.91, 0.45, 3.00, 1.07, 0.24, 0.42 and 0.07. Conclusion: 1. The change regulation of the nice compounds was Shang-hanlun>Zhushi-jiyanfang A > Yimenbafang, oxypaeoniflorin, albiflorin, paeoniflorin and benzoylpaeoniflorin in Zhushijiyanfang B Weishijia cangfang. chuanxinshiy-ongfang has the the lowest content of the nine compounds. 2. Total contents and proportion of the nine compounds are different due to different compatibility. The clinical curative effect is also different. Total contents of the nine compounds in Shanghanlun were 20.06 mg/ml which is used to relieve pain in the legs, in Zhushijiyanfang A was 8.72 mg/ml which is used to relieve pain caused by diabetes, in Zhushijiyanfang B was 8.72 mg/ml which is used to treat foot weakness, in Chuanxinshiyong-fang was 4.65 mg/ml which is used to treat wet beriberi, in Weishijiacangfang was 8.02 mg/ml which is used to treat wet beriberi, in Yimenbafang was 10.35 mg/ml which is used to treat peratodynia.

Levels of “Three Yin and Three Yang” syndrome differentiation / 国际中医中药杂志

“Three Yin and Three Yang” syndrome differentiation is a method and system generated from “Treatise on Febrile Diseases”. And it is a principle of syndrome differentiation and a criterion of treatment. Modern physicians give many descriptions on levels of “Three Yin and Three Yang” syndrome differentiation. There are a lot of different opinions on it, including “Yin and Yang”, ”three steps of Cluster analysis”, “one divided into two” combining with “one divided into three”, and “three steps of recognizing symptom, understanding disease and differentiating syndrome” theories. The author believes “Three Yin and Three Yang”syndrome differentiation consists of three levels:differentiating syndrome principle, differentiating syndrome category and differentiating syndrome type. Strengthening research on levels of syndrome differentiation helps to improve accuracy of syndrome differentiation, guide drug description and enhance clinical efficacy.

To Discuss the Diseases by the Side of Differentiation to ENT / 浙江中医药大学学报

Purpose]Research on otolaryngology disease properties and the classical prescription method, explore the mechanism and the application of the treatment of otolaryngology disease. [Methods]Selection of swel ing ear, ear vertigo, slowly closing pus ent common diseases such as ear, combined with the Treatise on Febrile Disease and Synopsis provisions, analysis of the disease by syndrome differentiation thinking, expound the classical prescription principles and the range for the treatment of the disease. [Results]Treating most otolaryngology disease can use the classical prescription, the curative effect of treatment of otolaryngology disease has obvious advantages. [Conclusion]It has been verified by classical prescription and clinical use, efficacy, and the system of subtlety, ingredients to streamline, familiar with the classical prescription treatment of otolaryngology disease, wil improve the level of physician treatment based on syndrome differentiation and patients to reduce the economic burden, has broad prospects.

Basing on the Original Language and Ideas Would Make A Better Way to Understand Treatise on Febrile Diseases / 浙江中医药大学学报

Objective Our purpose was to find out a better way for modern learner to understand the ancient medical book named as Treatise on Febrile Diseases. [Methods] We adopted the way of document research to find out the key points for modern learners. [Results] There were many interchangeable words, ancient and modern words and Nanyang dialect speech in the book. Further more, some drugs had been evolved in a state of flux. [Conclusion] Our conclusion was: To make a better understanding of Treatise on Febrile Diseases, we must put our fingers on the original language and ideas, not just focus on the clauses. And we cannot use contemporary language to explain ancient words;otherwise we would misunderstand the truth.